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AzaMDIPY, a new class of fluorophores (Inorg Chem 2022)

AzaMDIPY, a new class of fluorophores (Inorg Chem 2022)

 

Al(III) and Ga(III) Bisphenolate Azadipyrromethene-Based “N2O2” Complexes as Efficient NIR-Fluorophores

Aza-boron-dipyrromethenes (Aza-BODIPYs) are an increasingly studied class of fluorophores. They can be seen as an azadipyrromethene (“aza-DIPY”) ligand rigidified by a metalloid, a boron atom. Based on this idea, a series of complexes of group 13 metals (aluminum and gallium) have been synthesized and characterized. The impact of the metal and of the nature of the substituents of aza-DIPY core were investigated. The photophysical and electrochemical properties were determined, and an X-ray structure of an azaGaDIPY was obtained. These data reveal that azaGaDIPY and azaAlDIPY exhibit significant red-shifted fluorescence compared to their analogue aza-BODIPY. Their emission can go up to 800 nm for the maximum emission length and up to NIR-II for the emission tail. This, associated with their electrochemical stability (no metal release whether oxidized or reduced) makes them a promising class of fluorophores for optical medical imaging. Moreover, X-ray structure and molecular modeling studies have shown that this redshift seems to be more due to the geometry around the boron/metal than to the nature of the metal.

This work was published in Inorganic Chemistry by Bodio and coll. and resulted from a collaboration between ICMUB (UMR CNRS 6302), ENS de Lyon (UMR CNRS 5182), ISCR (UMR CNRS 6226), and IAB (INSERM U1209 / UMR CNRS 5309) [acces to the article click here]

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