MONCHAUD David Voir la fiche profil en français Français (FR)

  • MONCHAUD David
  • Statut : Researcher (DR)
  • Team : PD2A
  • Function : Researchers
  • Tags : Chemical biology, Molecular imaging, Photophysics, Synthetic chemistry
  • ORCID : 0000-0002-3056-9295
  • Address :

    ICMUB Institut de Chimie Moléculaire de l'Université de Bourgogne
    Bât. MIRANDE - Aille B - Bureau R16
    9 Avenue Alain Savary
    21000 Dijon – France

  • Tél : +33 380 399 043

2017 : CNRS Senior researcher (DR CNRS), ICMUB, CNRS UMR6302, Université de Bourgogne (Dijon, France).

2011 : Accreditation to Supervise Research diploma (i.e. Habilitation à Diriger des Recherches, HDR), ICMUB, CNRS UMR5260, Université de Bourgogne (Dijon, France).

2009 : CNRS researcher (CR CNRS), ICMUB, CNRS UMR5260, Université de Bourgogne. Lab of Pr. Franck Denat (Dijon, France).

2007 : CNRS researcher (CR CNRS), Curie Institute, CNRS UMR176. Lab of Dr. Marie-Paule Teulade-Fichou (Orsay, France).

2005 : CNRS researcher (CR CNRS), Collège de France, CNRS UPR285. Lab of Prof. Jean-Marie Lehn & Dr. M.-P. Teulade-Fichou (Paris, France).

2004 : Post-doctoral fellow (CNRS - Sanofi-Aventis grant), Collège de France. Lab of Prof. J.-M. Lehn, Dr. M.-P. Teulade-Fichou and Patrick Mailliet (Paris, France).

2003 : Post-doctoral fellow PharmaLEADS, (Paris, France).

2002 : Ph.D. in Chemistry, University of Geneva. Lab of Prof. Jérôme Lacour (Geneva, Switzerland).

2019-22: SEQUENTIA: Sequencing technologies adapted to the study of dementia (PI). FEDER-FSE Bourgogne 2014-2020.

2019-21: ANASTOMOSIS: Alternative Nucleic Acid Structures as Targets for Organic Molecules to Orchestrate Sustained genomic Instability and cellular Stress (PI). Plan Cancer 2014-2020 INSERM.

2019-21 : CoolCat: Constrained oligonucleotide-based catalysts (CoI). ANR (ANR-18-CE07-0017-03).

2018-20 : DEMENTIA: Exploiting genetic biomarkers of neurodegenerative diseases for developing early diagnostic tests and possible treatments (PI). ANR (ANR-17-CE17-0010-01).

2017-19 : STARFISH DNA: Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs (PI). European Commission (H2020-MSCA-IF-2016-750368).

2015-16 : Des sondes fluorescentes intelligentes pour déchiffrer le mécanisme d’action in cellulo d’agents anti-cancéreux (PI). FEDER (PARI2-DS3-2015).

2010-13 : TuMOR TAG: Tumor-specific multi-operating radiotracers targeting telomerase and G-quadruplex (PI) ANR (ANR-10-JCJC-709-1).

2010 : Unusual DNA structures as novel targets for anticancer therapy (PI). Programmes Interdisciplinaires CNRS (PIR-AO2-2010).

2008-10 : Development of molecular tools for imaging all types of cancers (PI). FABER (Conseil Régional de Bourgogne, FABER-2009-149E-149CE)  

86 published articles : cf. list

1 book edited : Biological relevance & therapeutic applications of DNA- and RNA-quadruplexes (Ed. D. Monchaud) © 2015 Future Science, Ltd.

1 patent : WO2010049915.

10 key publications:

DNA junction ligands trigger DNA damage and are synthetic lethal with DNA repair inhibitors in cancer cells. K. Duskova, P. Lejault, E. Benchimol, R. Guillot,S. Britton, A. Granzhan, D. Monchaud J. Am. Chem. Soc. 2020, 142, 424

Applications of guanine-quartets in nanotechnology and chemical biology. L. Stefan, D. Monchaud Nature Rev. Chem. 2019, 3, 650

Transcriptome-wide identification of transient RNA G-quadruplexes in human cells. S. Y. Yang, P. Lejault, S. Chevrier, R. Boidot, A. G. Robertson, J. M. Y. Wong, D. Monchaud Nature Commun. 2018, 9, 4730

Thermophilic tetramolecular G-quadruplex/hemin DNAzyme. H. Ju, Y. Guo, J. Chen, M. Cheng, D. Monchaud, J. Zhou Angew. Chem. Int. Ed. 2017, 56, 16636

Direct visualization of both DNA and RNA quadruplexes in human cells via an uncommon spectroscopic mechanism. A. Laguerre, J. M. Y. Wong, D. Monchaud Sci. Rep. 2016, 6, 32141.

Visualization of RNA-quadruplexes in live cells. A. Laguerre, K. Hukezalie, P. Winckler, F. Katranji, G. Chanteloup, M. Pirrotta, J.-M. Perrier-Cornet, J. M. Y. Wong, D. Monchaud J. Am. Chem. Soc., 2015, 137, 8521.

A twice-as-smart synthetic G-quartet: PyroTASQ is both a smart quadruplex ligand & a smart fluorescent probe. A. Laguerre, L. Stefan, M. Larrouy, D. Genest, J. Novotna, M. Pirrotta, D. Monchaud J. Am. Chem. Soc., 2014, 136, 12406.

A model of smart G-quadruplex ligand. R. Haudecoeur, L. Stefan, F. Denat, D. Monchaud J. Am. Chem. Soc., 2013, 135, 550.

Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae. J. S. Smith, Q. Chen, L. A. Yatsunyk, J. M. Nicoludis, M. S. Garcia, R. Kranaster, S. Balasubramanian, D. Monchaud, M.-P. Teulade-Fichou, L. Abramowitz, D. C. Schultz, F. B. Johnson Nature Struct. Mol. Biol., 2011, 18, 478.

An acyclic oligoheteroaryle that discriminates strongly between diverse G-quadruplex topologies. F. Hamon, E. Largy, A. Guédin-Beaurepaire, M. Rouchon-Dagois, A. Sibide, D. Monchaud, J.-L. Mergny, J.-F. Riou, C.-H. Nguyen, M.-P. Teulade-Fichou. Angew. Chem. Int. Ed., 2011, 50, 8745.

28 invited lectures ; 37 posters

Science popularization articles in Medecine/Sciences, Journal du CNRS and Encylopaedia Universalis

Highlights in CNRS News, Science & Avenir and Pour La Science

Recommended by the F-1000 in 2011, 2013 et 2018

Covers for New J. Chem., Chem. Eur. J., Nucleic Acids Res. and Eur. J. Org. Chem.

In interview for CQFD, radio broadcast of the RTS (Radio Télévision Suisse): here

« Chemistry & nucleic acids » (2h/year, M2 MMHD, Dijon, since 2017).

« Chemistry & cancers » (2h/year, M2R SCM, Dijon, since 2017).

« Chemistry & translational research in oncology » (4h/an, EPHE Dijon, since 2012).

>360 reviewed articles; cf. 1304537

Jury for associate professor positions : 32MCF4173 (ICMUB, Dijon, 2013), 32MCF0246 (ICMUB, Dijon, 2012), 85MCF1850 (Université Paris Descartes, Paris, 2010), 32MCF0255 (ICMUB, Dijon, 2010).

Jury for HDR : T. Caneque, Institut Curie, Paris, Jan. 2019; D. Gomez, IPBS Toulouse, Jan. 201

Jury for PhD thesis : Lab. O. Sénèque, CEA Grenobe, Dec. 2019; Lab. J.-L. Mergny, IECB Bordeaux, Dec. 2018 ; Lab. B. Therrien, Univ. Neuchatel (CH), Oct. 2018; Lab. M. Demeunynck, DPM Grenoble, Dec. 2016 ; Lab. J.-L. Mergny, IECB Bordeaux, Dec. 2016 ; Lab. F. Bolze, Strasbourg, Nov. 2015 ; Lab. R. Rodriguez, Gif/Yvette, Oct. 2015

Jury for Master 1 & 2 : ICMUB, Dijon, Juin 2012, 2013 & 2009 ; for M.Phil : Imperial College London (U.K.), Juin 2014.

Expert for funding agencies : European Research Council (ERC), Agence Nationale de la Recherche (ANR, France), Biotechnology and Biological Sciences Research Council (BBSRC, UK), Natural Sciences and Engineering Research Council (NSERC, Canada), Genesis Oncology Trust (New Zealand), Czech Academy of Science (CAS, Czech Republic), CEFIPRA (France & India), European Science Foundation (ESF, France).