MONCHAUD David Voir la fiche profil en français Français (FR)

image-profil
  • MONCHAUD David
  • Statut : Researcher (DR)
  • Team : PD2A
  • Function : Researchers
  • Tags : Chemical biology, Molecular imaging, Photophysics, Synthetic chemistry
  • ORCID : 0000-0002-3056-9295
  • Address :

    ICMUB Institut de Chimie Moléculaire de l'Université de Bourgogne
    Bât. MIRANDE - Aille B - Bureau R16
    9 Avenue Alain Savary
    21000 Dijon – France

  • Tél : +33 380 399 043
  • David.Monchaud@u-bourgogne.fr

2017 : CNRS Senior researcher (DR CNRS), ICMUB, CNRS UMR6302, Université de Bourgogne (Dijon, FRANCE).
2011 : Accreditation to Supervise Research diploma (i.e. Habilitation à Diriger des Recherches, HDR), ICMUB, CNRS UMR5260, Université de Bourgogne (Dijon, FRANCE).
2009 : CNRS researcher (CR CNRS), ICMUB, CNRS UMR5260, Université de Bourgogne. Lab of Pr. Franck Denat (Dijon, FRANCE).
2007 : CNRS researcher (CR CNRS), Curie Institute, CNRS UMR176. Lab of Dr. Marie-Paule Teulade-Fichou (Orsay, FRANCE).
2005 : CNRS researcher (CR CNRS), Collège de France, CNRS UPR285. Lab of Prof. Jean-Marie Lehn & Dr. M.-P. Teulade-Fichou (Paris, FRANCE).
2004 : Post-doctoral fellow (CNRS - Sanofi-Aventis grant), Collège de France. Lab of Prof. J.-M. Lehn, Dr. M.-P. Teulade-Fichou and Patrick Mailliet (Paris, FRANCE).
2003 : Post-doctoral fellow PharmaLEADS, (Paris, FRANCE).
2002 : Ph.D. in Chemistry, University of Geneva. Lab of Prof. Jérôme Lacour (Geneva, Switzerland).

2019-21 : CoolCat: Constrained oligonucleotide-based catalysts (CoI). ANR (ANR-18-CE07-0017-03).
2018-20 : DEMENTIA: Exploiting genetic biomarkers of neurodegenerative diseases for developing early diagnostic tests and possible treatments (PI). ANR (ANR-17-CE17-0010-01).
2017-19 : STARFISH DNA: Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs (PI). ERC (H2020-MSCA-IF-2016-750368).
2015-16 : Des sondes fluorescentes intelligentes pour déchiffrer le mécanisme d’action in cellulo d’agents anti-cancéreux (PI). FEDER (PARI2-DS3-2015).
2010-13 : TuMOR TAG: Tumor-specific multi-operating radiotracers targeting telomerase and G-quadruplex (PI) ANR (ANR-10-JCJC-709-1).
2010 : Unusual DNA structures as novel targets for anticancer therapy (PI). Programmes Interdisciplinaires CNRS (PIR-AO2-2010).
2008-10 : Development of molecular tools for imaging all types of cancers (PI). FABER (Conseil Régional de Bourgogne, FABER-2009-149E-149CE)  

75 published articles : cf. list

1 book edited : Biological relevance & therapeutic applications of DNA- and RNA-quadruplexes (Ed. D. Monchaud) © 2015 Future Science, Ltd.

1 patent : WO2010049915.

10 key publications:

Transcriptome-wide identification of transient RNA G-quadruplexes in human cells. S. Y. Yang, P. Lejault, S. Chevrier, R. Boidot, A. G. Robertson, J. M. Y. Wong, D. Monchaud Nature Commun. 2018, 9, 4730

Thermophilic tetramolecular G-quadruplex/hemin DNAzyme. H. Ju, Y. Guo, J. Chen, M. Cheng, D. Monchaud, J. Zhou Angew. Chem. Int. Ed. 2017, 56, 16636

Direct visualization of both DNA and RNA quadruplexes in human cells via an uncommon spectroscopic mechanism. A. Laguerre, J. M. Y. Wong, D. Monchaud Sci. Rep. 2016, 6, 32141.

Visualization of RNA-quadruplexes in live cells. A. Laguerre, K. Hukezalie, P. Winckler, F. Katranji, G. Chanteloup, M. Pirrotta, J.-M. Perrier-Cornet, J. M. Y. Wong, D. Monchaud J. Am. Chem. Soc., 2015, 137, 8521.

A twice-as-smart synthetic G-quartet: PyroTASQ is both a smart quadruplex ligand & a smart fluorescent probe. A. Laguerre, L. Stefan, M. Larrouy, D. Genest, J. Novotna, M. Pirrotta, D. Monchaud J. Am. Chem. Soc., 2014, 136, 12406.

A model of smart G-quadruplex ligand. R. Haudecoeur, L. Stefan, F. Denat, D. Monchaud J. Am. Chem. Soc., 2013, 135, 550.

Deciphering the DNAzyme activity of multimeric quadruplexes: insights into their actual role in the telomerase activity evaluation assay. L. Stefan, F. Denat, D. Monchaud J. Am. Chem. Soc., 2011,133, 20405

Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae. J. S. Smith, Q. Chen, L. A. Yatsunyk, J. M. Nicoludis, M. S. Garcia, R. Kranaster, S. Balasubramanian, D. Monchaud, M.-P. Teulade-Fichou, L. Abramowitz, D. C. Schultz, F. B. Johnson Nature Struct. Mol. Biol., 2011, 18, 478.

An acyclic oligoheteroaryle that discriminates strongly between diverse G-quadruplex topologies. F. Hamon, E. Largy, A. Guédin-Beaurepaire, M. Rouchon-Dagois, A. Sibide, D. Monchaud, J.-L. Mergny, J.-F. Riou, C.-H. Nguyen, M.-P. Teulade-Fichou. Angew. Chem. Int. Ed., 2011, 50, 8745.

Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. A. De Cian, G. Cristofari, P. Reichenbach, E. De Lemos, D. Monchaud, M.-P. Teulade-Fichou, K. Shin-ya, L. Lacroix, J. Lingner, J.-L. Mergny. Proc. Natl. Acad. Sci. USA, 2007, 104, 17347-17352

27 invited lectures ; 37 posters

« Chemistry & nucleic acids » (2h/year, M2 MMHD, Dijon, since 2017).

« Chemistry & cancers » (2h/year, M2R SCM, Dijon, since 2017).

« Chemistry & translational research in oncology » (4h/an, EPHE Dijon, since 2012).

>300 reviewed articles; cf. Publons.com 1304537

Jury for associate professor positions : 32MCF4173 (ICMUB, Dijon, 2013), 32MCF0246 (ICMUB, Dijon, 2012), 85MCF1850 (Université Paris Descartes, Paris, 2010), 32MCF0255 (ICMUB, Dijon, 2010).

Jury for HDR : Lab. D. Gomez, IPBS Toulouse, Jan. 2017 ; for PhD Thesis : Lab. B. Therrien, Univ. Neuchatel (CH), Oct. 2018; Lab. M. Demeunynck, DPM Grenoble, Dec. 2016 ; Lab. J.-L. Mergny, IECB Bordeaux, Dec. 2016 ; Lab. F. Bolze, Strasbourg, Nov. 2015 ; Lab. R. Rodriguez, Gif/Yvette, Oct. 2015 ; Master 1 & 2 : ICMUB, Dijon, Juin 2012, 2013 & 2009 ; for M.Phil : Imperial College London (U.K.), Juin 2014.

Expert for funding agencies : Agence Nationale de la Recherche (ANR, France), Biotechnology and Biological Sciences Research Council (BBSRC, UK), Natural Sciences and Engineering Research Council (NSERC, Canada), Genesis Oncology Trust (New Zealand), Czech Academy of Science (CAS, Czech Republic), CEFIPRA (France & India), European Science Foundation (ESF, France).